NIR-emissive Alkynylplatinum(II) Terpyridyl Complex as a turn-on selective probe for heparin quantification by induced helical self-assembly behaviour

The extent of self-assembly viametal–metal and π-π stacking interactions, induced by the polyanionic biopolymers, enables the class of alkynylplatinum(II) terpyridyl complexes to be applicable for the sensing of important biomacromolecules through the monitoring of spectral changes. Strong demand arises for the design of selective and practical detection techniques for the quantification of heparin, a highly negative-charged polysaccharidethat can function as anticoagulant, due to the prevention of hemorrhagic complications upon overdose usage.Aconvenient sensing protocol for the detection of UFH and LMWH, two common forms of heparins in clinical use, in buffer and biological medium has been demonstrated with the spectral changes associated with the induced self-assembly of a NIR-emissive platinum(II) complex. The detection range has been demonstrated to cover clinical dosage levels and the structurally similar analogues can be effectively differentiated based on their anionic charge density and the formation of supramolecular helical assembly of the platinum(II) complex with them ...postprin

Anion Binding Properties of Alkynylplatinum(II) Complexes with Amide-Functionalized Terpyridine: Host-Guest Interactions and Fluoride Ion-Induced Deprotonation

published_or_final_versio

NIR-emissive alkynylplatinum(II) terpyridyl complex as a turn-on selective probe for heparin quantification by induced helical self-assembly behaviour

The extent of self-assembly viametal–metal and π-π stacking interactions, induced by the polyanionic biopolymers, enables the class of alkynylplatinum(II) terpyridyl complexes to be applicable for the sensing of important biomacromolecules through the monitoring of spectral changes. Strong demand arises for the design of selective and practical detection techniques for the quantification of heparin, a highly negative-charged polysaccharidethat can function as anticoagulant, due to the prevention of hemorrhagic complications upon overdose usage.Aconvenient sensing protocol for the detection of UFH and LMWH, two common forms of heparins in clinical use, in buffer and biological medium has been demonstrated with the spectral changes associated with the induced self-assembly of a NIR-emissive platinum(II) complex. The detection range has been demonstrated to cover clinical dosage levels and the structurally similar analogues can be effectively differentiated based on their anionic charge density and the formation of supramolecular helical assembly of the platinum(II) complex with them ...postprin

Molecular Design of Novel Classes of Luminescent Transition Metal Complexes and Their Use in Sensing, Biolabeling, and Cell Imaging

The design and synthesis of a number of luminescent transition metal complexes will be described, and their rich photophysical properties will be examined. Upon the incorporation of various functionalities to the ancillary ligands, not only will their electronic absorption and emission properties be tuned, but also they may serve as optical and luminescent sensors for ions and molecules of biological interest and as reagents and probes for biolabeling and cell imaging

NIR-Emissive Alkynylplatinum(II) Terpyridyl Complex as a turn-on selective probe for heparin quantification by induced helical self-assembly behaviour

Poster Session: P069 (A0678

NIR-emissive alkynylplatinum(II) terpyridyl complex as a turn-on selective probe for heparin quantification by induced helical self-assembly behaviour

NIR-emissive heparin sensor: A convenient and selective sensing protocol has been established for the quantification of both unfractionated and low-molecular-weight heparin, based on the heparin-induced helical self-assembly feature of a NIR-emissive alkynylplatinum(II) terpyridyl complex (see scheme), for which the detection range covers the clinical dosage level. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.link_to_subscribed_fulltex

Phosphate derivative-induced supramolecular assembly and NIR-emissive behaviour of alkynylplatinum(II) terpyridine complexes for real-time monitoring of enzymatic activities

Conference Theme: Understanding the Interplay Between Organic and Inorganic MaterialsSession II, no.1

NIR-Emissive Alkynylplatinum(II) Terpyridyl Complex as a turn-on selective probe for heparin quantification by induced helical self-assembly behaviour

No. PO15

Aptamer-induced self-assembly of a NIR-emissive platinum(ii) terpyridyl complex for label- and immobilization-free detection of lysozyme and thrombin

With the aptamer-induced self-assembly feature of NIR-emissive platinum(ii) terpyridyl complex, a "proof-of-principle" concept in label- and immobilization-free probing strategies of lysozyme and thrombin has been demonstrated with good selectivity and specificity. © The Royal Society of Chemistry.link_to_subscribed_fulltex

Towards thermochromic and thermoresponsive near-infrared (NIR) luminescent molecular materials through the modulation of inter- and/or intramolecular Pt⋯Pt and π-π Interactions

A series of mononuclear and dinuclear alkynylplatinum(ii) terpyridyl complexes has been found to show inter- and/or intramolecular aggregation in fluid solution state at low temperature or even at room temperature. Drastic colour changes and near infra-red (NIR) emission enhancement as well as broad and poorly resolved resonance signals in the 1H NMR spectra were observed. Such aggregation processes have been probed by 1H NMR, electronic absorption and emission spectroscopy. © 2010 The Royal Society of Chemistry.link_to_subscribed_fulltex